The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies
نویسندگان
چکیده
منابع مشابه
The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies
BACKGROUND The results of previous studies assessing the association between the 5-HTTLPR polymorphism of serotonin transporter gene and irritable bowel syndrome (IBS) are inconsistent. The aim of this study was to clarify the association between the 5-HTTLPR mutation and the presence of IBS and its subtypes with a meta-analysis of 25 studies. METHODS A thorough search for case-control studie...
متن کاملAuthor's response to reviews Title:The Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Irritable Bowel Syndrome: A Meta-Analysis of 25 Studies Authors:
Author's response to reviews: Dear editors: Thank you for your check of our article. We have made a careful revision according to your suggestions as followings. 1. We have revised the figure legend in our article accordingly. 2. We have added the " Competing Interest " section in our manuscript. 3. We have revised the abstract (262 words) of our manuscript accordingly. 4. We have added in the ...
متن کامل5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex.
BACKGROUND Conflicting data exist on the association between functional polymorphisms in the serotonin reuptake transporter (SERT) gene (SLC6A4) and irritable bowel syndrome (IBS). This may be partly because of small participant numbers and varying ethnic origin and sex within the cohorts studied. AIM To reassess the potential association between the SERT polymorphisms 5-HTTLPR and STin2 in b...
متن کاملMeta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy.
In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was likely the most studied genetic variant as predictor of antidepressant response. Nevertheless results are not consistent across studies and previous meta-analysis, since various factors seem to modulate its effect on antidepressant response. With the aim of clarifying this issue, we systematically reviewed li...
متن کاملSerotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls.
BACKGROUND Polymorphisms in serotonin re-uptake transporter (SERT or SLC6A4) gene may play role in disturbance in gut function in irritable bowel syndrome (IBS). The aim of this study was to evaluate the association between SLC6A4 polymorphism of SERT-P and serotonin (5-hydroxytryptamine, 5-HT) concentration in IBS as compared with controls. METHODS 150 patients with IBS (Rome-III criteria) a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Gastroenterology
سال: 2014
ISSN: 1471-230X
DOI: 10.1186/1471-230x-14-23